SPATIAL SOUND SYSTEM TO AID INTERACTIVITY IN A HUMAN CENTRED DESIGN EVALUATION OF AN AIRCRAFT CABIN ENVIRONMENT

There is a lot of research towards the concept of 3D sound in virtual reality environments. With the incipient growth in the significance of designing more realistic and immersive experiences for a Human Centred Design (HCD) approach, sound perception is believed to add an interactive element in maximizing the human perspective. In this context, the concept of an audio-visual interaction model between a passenger and a crew member in an immersive aircraft cabin environment is studied and presented in this paper. The study focuses on the design and usability of spatial sources as an interactive component in a regional aircraft cabin design for Human in the Loop evaluation. Sound sources are placed among the virtual manikins acting as passengers with the aim of building a realistic virtual environment for the user enacting the role of a crew member. The crew member, while walking throughthe cabin can orient and identify the position of the sound source inside the immersive Cabin environment. We review the 3D sound approaches and cues for sound spatialization in a virtual environment and propose that audio-visual interactivity aids the immersive Human centred design analysis

Relationship between electroencephalographic data and comfort perception captured in a Virtual Reality design environment of an aircraft cabin

Successful aircraft cabin design depends on how the different stakeholders are involved since the first phases of product development. To predict passenger satisfaction prior to the manufacturing phase, human response was investigated in a Virtual Reality (VR) environment simulating a cabin aircraft. Subjective assessments of virtual designs have been collected via questionnaires, while the underlying neural mechanisms have been captured through electroencephalographic (EEG) data. In particular, we focused on the modulation of EEG alpha rhythm as a valuable marker of the brain's internal state and investigated which changes in alpha power and connectivity can be related to a different visual comfort perception by comparing groups with higher and lower comfort rates. Results show that alpha-band power decreased in occipital regions during subjects' immersion in the virtual cabin compared with the relaxation state, reflecting attention to the environment. Moreover, alpha-band power was modulated by comfort perception: lower comfort was associated with a lower alpha power compared to higher comfort. Further, alpha-band Granger connectivity shows top-down mechanisms in higher comfort participants, modulating attention and restoring partial relaxation. Present results contribute to understanding the role of alpha rhythm in visual comfort perception and demonstrate that VR and EEG represent promising tools to quantify human-environment interactions

Analysis of MUC4 expression in the prostatic adenocarcinoma and its pathological implications

Background: Expression of various types of mucins has been documented in several malignancies and seems to play a sentinel role in some epithelial malignancies. MUC1 and MUC4 are two transmembrane mucins that are involved in cell signalling events that drive the proliferation of cells. Therefore, mucins may be important biomarkers for early diagnosis and targeted therapy due to their frequently altered expression pattern in carcinomas. The objective of the study was to determine the expression pattern of MUC-4 in prostate cancer and to correlate the expression with clinicopathological parameters.Methods: Thirty cases of prostate carcinomas of different grades were selected from the case files of our institute for the study. Immunohistochemistry was done on all cases using monoclonal antibodies against MUC- 4 by the avidin biotin technique. The expression and pattern of staining were analyzed .Staining pattern in the adjacent benign areas were also noted.Results: Our study showed that expression of MUC4 was considerably down regulated in prostate cancer tissues when compared to normal or benign prostatic tissue. Few cases of prostate cancer showed a moderate staining while majority cases of adjacent normal areas were moderate to strongly positivity.Conclusions: The results of our study implies that MUC4 is down regulated in prostate cancer and this may be of significance for diagnostic application and tumor progression in prostate cancer. Since MUC4 is known to modulate HER2/ErbB2 signalling it may prospectively prove to be useful in prostate cancer therapy

Apocyclops cmfri sp. nov. (Cyclopoda : Cyclopoida : Cyclopidae), a new copepod species from Arabian Sea off Karwar, Karnataka, India

A new species of Apocyclops Lindberg (Cyclopoda: Cyclopoida: Cyclopidae) is described based on specimens collected from marine waters of Karwar, Karnataka, India. At present, there are 11 valid and accepted species excluding one extinct species (fossil) in this genus which are widely distributed in fresh and brackishwater areas in the tropics and subtropics. Five valid species of Apocyclops are reported from the Asian region, including two species from India. The new species is closer to the previously reported Indian species, A. royi (Lindberg) and A. dengizicus dengizicus (Lepeshkin). Apocyclops cmfri sp. nov. differs from these in the size of caudal rami, in the characteristic shape of disto-medial part of coxa and basis of first to fourth pleopods (P1-P4) and in the presence of a single broad spinous expansion with a pointed tip in between exopod and endopod in basis of P1 to P4. Only one terminal spine is present in the second segment of endopod of P1. In P2 to P4, both exopod and endopod terminate in a spine and a seta of almost equal size. Maxillule highly dentate and maxilla basis form a large dentate claw with inner serration. All these characters form distinct identification features of the new species in comparison with the 12 accepted species under the genus. A key to all the species of the genus including the newly described species is proposed here. Molecular identification of the new species was carried out by mitochondrial cytochrome c oxidase 1 (CO1) gene sequencing and the sequence was submitted to NCBI, GenBank. Genetic differentiation and divergence between A. cmfri sp. nov. and species belonging to other closely related genera; Thermocyclops, Mesocyclops and Eucyclops were compared using CO1 gene sequences. The new species belonging to Apocyclops showed significant divergence from Apocyclops borneoensis with K2P value of 10.2% and from species under the genera Mesocyclops, Thermocyclops and Eucyclops with K2P values of 26.6, 27.5and 34.9% respectively

Determination of surface finish and Metal Removal Rate by varying parameters in wirecut Electrical Discharge Machining and optimizing using genetic algorithm

Wire Electric Discharge Machining (WEDM) is one of the greatest innovations in the tooling and machining industry. This process has brought dramatic improvements in accuracy, quality, productivity and earnings. Before wire EDM, costly processes were often used to produce finished parts. Now with the aid of computer and wire EDM machines, extremely complicated shapes can be cut automatically, precisely and economically even in materials as hard as carbide. The selection of optimum machining parameters in WEDM is an important step. Improperly selected parameters may result in serious problems like short-circuiting of wire, wire breakage and work surface damage which is imposing certain limits on the production schedule and also reducing productivity. The objective of the present work is to investigate the effects of the various Wire cut EDM process parameters on the surface quality, maximum material removal rates and obtain the optimal sets of process parameters so that the quality and MRR of machined parts can be optimized. Experiments will be conducted on the pieces by parameters. The material used for machining is Aluminium alloy. The process parameters considered are Pulse Time on, Pulse Time off, Input Power, Wire Feed, Servo Voltage and Wire Tension. The optimization will be done by using Genetic Algorithm. The above work is performed in English at WinWill Technical Services, located in Hyderabad, India, for a period of 4months

Comparative Evaluation of Remineralizing Potential of a Paste Containing Bioactive Glass and a Topical Cream Containing Casein Phosphopeptide-Amorphous Calcium Phosphate: An in Vitro Study

Objective:To evaluate and compare the remineralization potential of a dentifrice containing bioactive glass and a topical cream containing casein phosphopeptide-amorphous calcium phosphate (CPP-ACP) in remineralizing artificial carious lesion on enamel. Material and Methods:Forty-five freshly extracted human permanent premolar teeth were selected. Samples were divided into three groups: GI - regular tooth paste without specific remineralizing agent; GII - tooth paste containing calcium sodium-phosphosilicate (novamin) and GIII - topical cream containing casein phosphopeptide-amorphous calcium phosphate. All the sound enamel samples were viewed under scanning electron microscope (SEM) to assess the topographical pictures of enamel surface and energy dispersing x-ray analysis (EDAX) was done to estimate quantitatively the amounts of mineral (calcium and phosphorous). The mineral content of calcium and phosphorus after demineralization in each group was noted. The samples were then subjected to SEM and EDAX. Results:GI does not show any increase in the calcium and phosphorus after applying toothpaste without any remineralizing agent but GII and GIII showed a net increase in calcium and phosphorous values after applying concern-remineralizing agents. Inter group comparison showed GIII yield higher net calcium and phosphorous values than GII. Conclusion:Two remineralizing agents showed remineralization potential on enamel surfaces. Casein phosphopeptide-amorphous calcium phosphate showed better remineralizing potential than calcium sodium phosphosilicate. Hence CPP-ACP can be considered as the material of choice in remineralizing early enamel carious lesions

Not Available

Not AvailableA new species of Apocyclops Lindberg (Cyclopoda: Cyclopoida: Cyclopidae) is described based on specimens collected from marine waters of Karwar, Karnataka, India. At present, there are 11 valid and accepted species excluding one extinct species (fossil) in this genus which are widely distributed in fresh and brackishwater areas in the tropics and subtropics. Five valid species of Apocyclops are reported from the Asian region, including two species from India. The new species is closer to the previously reported Indian species, A. royi (Lindberg) and A. dengizicus dengizicus (Lepeshkin). Apocyclops cmfri sp. nov. differs from these in the size of caudal rami, in the characteristic shape of disto-medial part of coxa and basis of first to fourth pleopods (P1-P4) and in the presence of a single broad spinous expansion with a pointed tip in between exopod and endopod in basis of P1 to P4. Only one terminal spine is present in the second segment of endopod of P1. In P2 to P4, both exopod and endopod terminate in a spine and a seta of almost equal size. Maxillule highly dentate and maxilla basis form a large dentate claw with inner serration. All these characters form distinct identification features of the new species in comparison with the 12 accepted species under the genus. A key to all the species of the genus including the newly described species is proposed here. Molecular identification of the new species was carried out by mitochondrial cytochrome c oxidase 1 (CO1) gene sequencing and the sequence was submitted to NCBI, GenBank. Genetic differentiation and divergence between A. cmfri sp. nov. and species belonging to other closely related genera; Thermocyclops, Mesocyclops and Eucyclops were compared using CO1 gene sequences. The new species belonging to Apocyclops showed significant divergence from Apocyclops borneoensis with K2P value of 10.2% and from species under the genera Mesocyclops, Thermocyclops and Eucyclops with K2P values of 26.6, 27.5and 34.9% respectively.Not Availabl

The GenomeAsia 100K Project enables genetic discoveries across Asia

The underrepresentation of non-Europeans in human genetic studies so far has limited the diversity of individuals in genomic datasets and led to reduced medical relevance for a large proportion of the world’s population. Population-specific reference genome datasets as well as genome-wide association studies in diverse populations are needed to address this issue. Here we describe the pilot phase of the GenomeAsia 100K Project. This includes a whole-genome sequencing reference dataset from 1,739 individuals of 219 population groups and 64 countries across Asia. We catalogue genetic variation, population structure, disease associations and founder effects. We also explore the use of this dataset in imputation, to facilitate genetic studies in populations across Asia and worldwide.Published versio

Proceedings of the 6th International Conference on Modeling and Simulation in Civil Engineering

This conference proceedings contains articles on the various research ideas of the academic community and technical researchers presented at the 6th International Conference on Modeling and Simulation in Civil Engineering (ICMSC 2022). ICMSC 2022 was organized by the Department of Civil Engineering, TKM College of Engineering, Kollam, Kerala, India on December 1-3, 2022. The main aim of this conference is to bring together leading academicians, researchers, technocrats, practitioners, and students to exchange and share their experiences and research outputs on all aspects of Civil Engineering, especially related to the modeling and simulation in Civil Engineering.  Conference Title: 6th International Conference on Modeling and Simulation in Civil EngineeringConference Acronym:  ICMSC 2022Conference Date: 1-3 December 2022Conference Location: IndiaConference Organizer: Department of Civil Engineering, TKM College of Engineering, Kollam, Kerala, Indi